SINGLE-REACTOR METHOD OF PERGOLIDE SYNTHESIS

摘要

FIELD: organic chemistry. SUBSTANCE: method involves interaction of 8,9-dihydroelimoclavine with 1-iodopropane, sulfonyl halide and alkaline metal thiomethoxide without isolation of intermediate compounds. Solvents - N-methylpyrrolidone and pyridine are used by this method. Method can be used in pharmacy of the known drug pergolide used for treatment of patients with Parkinson's disease. EFFECT: improved method of synthesis. 2 cli