| 摘要 |
Provided is a method for selecting a chemotherapeutic agent for treating cancer, which method comprises: (a) testing a sample comprising cells that substantially do not express p21 and/or in which p21 protein is substantially undetectable, or an extract therefrom for the level of expression of Cyclin D1 of for the abundance of Cyclin D1 protein; and (b) if Cyclin D1 is over expressed, and/or Cyclin D1 protein is present at elevated levels, selecting for treatment a chemotherapeutic agent comprising a taxane; (c) if Cyclin D1 is not over expressed and/or Cyclin D1 protein is substantially not present at elevated levels, selecting for treatment a chemotherapeutic agent comprising an agent other than a taxane. Also provided is a kit for selecting a chemotherapeutic agent for treatment, which kit comprises: (a) a means for identifying cells in which p21 is substantially not expressed and/or p21 protein is substantially undetectable; and (b) a means for testing for the level of expression of Cyclin D1 or for the abundance of Cyclin D1 protein in cells or in a sample therefrom.
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