| 摘要 |
<p>A nucleic acid which encodes a polypeptide which produces a protective immune response against an alpha-virus such as a Venezuelan Equine Encephalitis Virus, in a mammal to which it is administered, said nucleic acid lacking a competant nuclear targeting signal in the capsid gene. The nucleic acids of the invention are expressed at enhanced levels in vectors such as adenovirus vectors. In particular there is described a deletion mutant of an alpha-virus. Vectors such as recombinant adenoviruses which express the deletion mutant are potentially of use as vaccines.</p> |
