发明名称 |
Verfahren zur Herstellung von 1-(2'-Deoxy-2',2'-difluoro-D-ribofuranosyl)-4-amino-pyrimidin-2-on-hydrochlorid |
摘要 |
<p>This invention provides a process for preparing gemcitabine hydrochloride which comprises deblocking beta -1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-amin opyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol in an environment essentially free of water; treating the resulting solution with hydrochloric acid and an antisolvent; and recovering the resulting solid gemcitabine hydrochloride.</p> |
申请公布号 |
DE69509624(T2) |
申请公布日期 |
1999.10.07 |
申请号 |
DE1995609624T |
申请日期 |
1995.11.09 |
申请人 |
ELI LILLY AND CO., INDIANAPOLIS |
发明人 |
BERGLUND, RICHARD ALAN |
分类号 |
C07H19/06;(IPC1-7):C07H19/073 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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