发明名称 |
Assay for specific strains of multiple disease related conformations of a protein |
摘要 |
Assay methodology of the invention allows for: (1) determining if a sample contains a conformation of a protein which is associated with disease and the concentration and amount of such if present; (2) determining the amount of protease resistant disease related protein in a sample and by subtracting that amount from the total amount of disease related protein present determining the amount of protease sensitive disease protein in the sample; and (3) determining the strain and incubation time of a disease related protein by (i) relating the relative amounts of protease resistant and protease sensitive protein to known strains to thereby determine the strain; and (ii) plotting the concentration of protease sensitive protein on a graph of incubation time versus concentration of protease sensitive protein for known strains to predict the incubation time of an unknown strain of pathogenic protein in a sample.
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申请公布号 |
US2002001817(A1) |
申请公布日期 |
2002.01.03 |
申请号 |
US20010901865 |
申请日期 |
2001.07.09 |
申请人 |
PRUSINER STANLEY B.;SAFAR JIRI G.;COHEN FRED E. |
发明人 |
PRUSINER STANLEY B.;SAFAR JIRI G.;COHEN FRED E. |
分类号 |
C07K14/47;C07K16/28;G01N33/569;G01N33/68;(IPC1-7):G01N33/53;C07K1/00;C12P21/08;C08H1/00;C07K14/00;C07K16/00;G01N33/543 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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