| 摘要 |
The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting alpha5beta1 integrin in the tissue with an agent that interferes with specific binding of the alpha5beta1 integrin to a ligand expressed in the tissue; and methods of identifying angiogenesis in a tissue, by contacting the tissue with an agent that specifically binds alpha5beta1 integrin, and detecting specific binding of the agent to alpha5beta1 integrin associated with a blood vessel in the tissue. Also provided are methods of diagnosing a pathological condition characterized by angiogenesis in a tissue in an individual. The invention further provides methods of reducing or inhibiting angiogenesis in a tissue in an individual, by administering to the individual an agent that interferes with the specific binding of alpha5beta1 integrin to a ligand expressed in the tissue; and methods of reducing the severity of a pathological condition associated with angiogenesis in an individual, by administering to the individual an agent that interferes with specific binding of alpha5beta1 integrin to a ligand in a tissue associated with the pathological condition. The invention also provides methods of identifying an agent that reduces or inhibits angiogenesis associated with alpha5beta1 integrin expression in a tissue by contacting a tissue exhibiting angiogenesis associated with alpha5beta1 integrin expression with an agent, and detecting a reduction or inhibition of angiogenesis in the tissue.
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