主权项 |
1. A compound of formula (A), wherein —R1 is X1, X6, X7, X9 and X10 are halogen, C1-C4 linear branched or cyclic alkyl optionally substituted with one or more fluorine atoms; X2, X3, X4, X5 and X8, are hydrogen, halogen, C1-C4 linear branched or cyclic alkyl optionally substituted with one or more fluorine atoms; with the proviso that at least one of X2, X3, X4, and X5 is not hydrogen R2 is a C3-C6 linear branched or cyclic alkyl optionally substituted with phenyl, with one or more fluorine atoms or with trifluoromethyl-furanyl; R2′ is hydrogen, F, C1-C3 linear or branched alkyl optionally substituted with one or more fluorine atoms; or R2 and R2′ together with the carbon atom they are attached to form a C3-C6 cycloalkyl ring; —R3 is Y1 is halogen; Y1′ is C1-C3 linear branched or cyclic alkyl optionally substituted with one or more fluorine atoms; Y2 is cyano or methoxyphenyl, C1-C3 linear branched or cyclic alkyl optionally substituted with one or more fluorine atoms; Y3 is hydrogen, halogen or methoxyphenyl; Y4 is hydrogen, halogen, N-methylpyrazolyl or a C1-C3 linear branched or cyclic alkoxy optionally substituted with one or more fluorine atoms, Y5 is hydrogen halogen, cyano, or a C1-C3 linear branched or cyclic alkyl optionally substituted with one or more fluorine atoms; with the proviso that at least one of Y4 and Y5 is not hydrogen; Y6 is halogen, C1-C3 linear branched or cyclic alkyl optionally substituted with one or more fluorine atoms, or a C1-C3 linear branched or cyclic alkoxy optionally substituted with one or more fluorine atoms; enantiomers, enantiomerically enriched mixtures, and pharmaceutically acceptable salts thereof. |