发明名称 |
COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES |
摘要 |
Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses. |
申请公布号 |
EP2714685(B1) |
申请公布日期 |
2016.10.19 |
申请号 |
EP20120793459 |
申请日期 |
2012.05.24 |
申请人 |
AMBRX, INC. |
发明人 |
MIAO, ZHENWEI;ATKINSON, KYLE, C.;BIROC, SANDRA;BUSS, TIMOTHY;COOK, MELISSA;KRAYNOV, VADIM;MARSDEN, ROBIN;PINKSTAFF, JASON;SKIDMORE, LILLIAN;SUN, YING;SZYDLIK, AGNIESZKA;LOPEZ DE VALENTA, DELIA IANINA |
分类号 |
C07D417/12;A61K31/337;A61K31/427;A61K39/00;A61K39/395;A61K47/48;A61P35/00;C07D207/325;C07D401/12;C07K5/02;C07K5/06;C07K16/28 |
主分类号 |
C07D417/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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