发明名称 |
PROCESS FOR THE PREPARATION OF ENOLATE SALTS OF 4-FLUORO-2-HYDROXYMETHYLENE-3-OXO-BUTYRATES |
摘要 |
Enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates of formula wherein R1 is C1-10 alkyl, R2 and R3 are independently hydrogen or fluorine, M is an alkali or alkaline earth metal, and n is 1 or 2, are prepared from enolate salts of the corresponding 4-fluoro-3-oxobutyrates and carbon monoxide. The enolate salts of formula I can be alkylated or acylated to obtain the corresponding enol ethers and esters. The 4-fluoro-3-oxobutyrate starting material can be prepared from 1,1-difluoroethyl methyl ethers by SbF5-catalyzed fluoromethane elimination followed by halogen exchange with lithium chloride, reacting the thus obtained fluoroacetyl chloride with ketene and quenching with the appropriate alcohol R1—OH. |
申请公布号 |
EP2593420(B1) |
申请公布日期 |
2016.10.19 |
申请号 |
EP20110731280 |
申请日期 |
2011.07.11 |
申请人 |
LONZA LTD |
发明人 |
DRESSEL, MARTINA;HANSELMANN, PAUL;ZARAGOZA DÖRWALD, FLORENCIO |
分类号 |
C07C67/14;C07C51/58;C07C51/62;C07C67/31;C07C67/343;C07C69/14;C07C69/738 |
主分类号 |
C07C67/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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