Treating basal-like genotype cancers

摘要

Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus TAP repeat (BIR).

主权项

1. A method of treating a subject with cancer, the method comprising:
(a) selecting a subject with a breast cancer, wherein the breast cancer is a basal-like genotype cancer and is HER2 non-amplified, and wherein the breast cancer shows reduced levels of DR5/DDX3/cIAP1 complex as compared to a control; and (b) administering to the subject a death receptor agonist, wherein the death receptor agonist is a DR5 agonist.