发明名称 |
Process for preparing N-methyl-3-(P-trifluoromethylphenoxy)-3-phenyl-propylamine and salts thereof in a highly pure form |
摘要 |
The present invention relates to a process for preparing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenyl-propylamine and pharmaceutically acceptable acid addition salts thereof. The process in accordance with the present invention comprises reacting 1-phenyl-3-(N-methylamine) propane-1-ol with 1-chloro-4-trifluoromethylbenzene, in the presence of an hydroxide of an alkaline metal in a dipolar aprotic solvent non saponifiable in reaction conditions. The process in accordance with the present invention further comprises a final crystallization step which allows to obtain the active ingredient in a highly pure crystalline form.
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申请公布号 |
US5847214(A) |
申请公布日期 |
1998.12.08 |
申请号 |
US19970889162 |
申请日期 |
1997.07.07 |
申请人 |
LAPORTE ORGANICS FRANCIS S.P.A. |
发明人 |
AROSIO, ROBERTO;BERATTO, STEFANO GIOVANNI VITTORIO;ROSSETTI, VITTORIO |
分类号 |
C07C213/08;C07C217/48;(IPC1-7):C07C213/06 |
主分类号 |
C07C213/08 |
代理机构 |
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地址 |
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