NOVEL 2-(N-CYANOIMINO)THIAZOLIDIN-4-ONE DERIVATIVES

摘要

This invention provides novel 2-(N-cyanoimino)thiazolidin-4-one derivative s represented by formula I or a pharmaceutically acceptable salt or solvate thereof: wherein ring A represents a benzene ring, a condensed ring or a heterocyclic ring, each of which may be substituted by one or more substituents selected from a straigh t or branched C1 - C4 alkyl group, a haloalkyl group, a halogen atom or -OR5, R1 represents a single bond, an oxygen atom, a sulfur atom, a methyne group, a straight or branched C1 - C4 alkylene or alkenylene group optionally substituted by a phenyl group, R6-X, X-R6, X-R6-X, R6-X-R6, -C(=O)-NR7- or -NR7-C(=O)-, R2 and R3 are the same or different and each represents a hydrogen atom, a C 1 - C4 alkyl group, -OR8 or a halogen atom, R4 represents a hydrogen atom or a C1 - C4 alkyl group, R5 represents a hydrogen atom or a C1 - C4 alkyl group, R6 represents a straight or branched C1 - C4 alkylene or alkenylene group, R7 represents a hydrogen atom or a C1 - C4 alkyl group, R8 represents a hydrogen atom, a C1 - C4 alkyl group or an aralkyl group, X represents an oxygen atom or a sulfur atom. They have excellent activities of lowering triglyceride and cholesterol levels, and are useful for preventing from and/or treating hyperlipidemia and related complications.