发明名称 |
POSITION-SPECIFIC INSERTION VECTORS AND METHOD OF USING SAME |
摘要 |
The present invention provides vectors for the efficient and position-specific integration of expressible, exogenous nucleotide sequences into cellular genomes. This invention takes advantage of the discovery of a position-specific endonuclease and position-specifid insertion markers for the design of said vectors. In addition, a gene comprising a recombinant nucleic acid molecule encoding a polypeptide possessing the biological activity of a position-specific endonuclease, wherein the biological activity of said endonuclease is the catalysis of position-specific insertion of genetic material carried between the position-specific integration markers, is disclosed. |
申请公布号 |
WO9005787(A1) |
申请公布日期 |
1990.05.31 |
申请号 |
WO1989US05244 |
申请日期 |
1989.11.20 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SANDMEYER, SUZANNE, B. |
分类号 |
A61K38/46;A61K39/395;A61K39/44;A61P35/00;C07K1/22;C07K14/00;C07K14/195;C07K14/41;C07K16/00;C07K16/40;C12N5/10;C12N9/16;C12N9/22;C12N15/02;C12N15/09;C12N15/81;C12N15/85;C12N15/90;C12P21/08;C12R1/865 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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