Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an effective amount of a 12a-deoxytetracycline represented by the following general formula <IMAGE> The method is effective in the treatment of various articular diseases characterized by excessive collagen destruction.
申请公布号
US5258371(A)
申请公布日期
1993.11.02
申请号
US19920891554
申请日期
1992.05.29
申请人
KURARAY CO., LTD.;UNIV NEW YORK STATE RES FOUND
发明人
GOLUB, LORNE M.;RAMAMURTHY, NANGAVARUM S.;MCNAMARA, THOMAS F.;GREENWALD, ROBERT A.;KAWAI, TSUTOMU;HAMASAKI, TAKASHI;SHIMAMURA, MICHIYA;KOBAYASHI, GORO;TAKIGAWA, TETSUO;IWATA, HISASHI
