Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use

摘要

This invention relates to highly active and solid pharmaceutical preparations rapidly releasing the active substance for the treatment of diabetes, particularly: 1. liquid formulations of glibenclamide consisting of 1 part of glibenclamide and 4 to 1500 parts of liquid sugar alcohols such as 70% sorbitol solution or glycol such as propylene glycol, hexylene glycol, di-, tri- or polyethylene glycol having a molecular weight from 76 to 600, optionally 0.5 to 2 moles of an alkaline reacting substance and other drug additives; 2. solid formulations of glibenclamide consisting of 1 part of glibenclamide, 4 to 30 parts of sugar alcohols, preferably 70% sorbitol solution, optionally dilute in alcohol, 30 to 150 parts of pharmacologically safe excipients, carrier mterials or other drug additives; and this invention also relates to a process for the production of a molecularly disperse solution or active substance alloy of glibenclamide or another sparingly soluble substance selected from the group consisting of sulfonyl ureas or substances and/or compounds having similar chemico-physical properties.