METHODS AND COMPOSITIONS FOR MODULATION OF GROWTH RESPONSE

摘要

The present invention details methods for the treatment of cancer. In particular, it concerns the induction of apoptosis of cancer cells following treatment with c-Abl and p300, which control levels of wild-type p53. Also included are methods of combination therapy wherein cells lacking p53 are supplemented with c-Abl, p300 and wild-type p53 to induce an apoptotic responses.