摘要 |
Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent. |
申请人 |
ALZA CORPORATION;BRODBECK, KEVIN, J.;GAYNOR-DUARTE, ANN, T.;SHEN, THEODORE, T. |
发明人 |
BRODBECK, KEVIN, J.;GAYNOR-DUARTE, ANN, T.;SHEN, THEODORE, T. |