| 发明名称 |
METHOD FOR PREPARING SUBMICRON PARTICLE SUSPENSIONS |
| 摘要 |
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of : (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution ; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound ; and (ii i) seeding the first solution or the second solvent or the presuspension.</SDOA B>
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| 申请公布号 |
CA2431705(A1) |
申请公布日期 |
2002.07.18 |
| 申请号 |
CA20012431705 |
申请日期 |
2001.12.20 |
| 申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
BRYNJELSEN, SEAN;WERLING, JANE;REBBECK, CHRISTINE L.;DOTY, MARK J.;SRIRAM, RAJARAM;KIPP, JAMES E.;WONG, JOSEPH CHUNG TAK |
| 分类号 |
C07D407/14;A61K9/10;A61K9/14;A61K9/16;A61K31/495;A61K31/496;A61K47/12;A61K47/14;A61K47/18;A61K47/20;A61K47/24;A61K47/28;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61P31/10;(IPC1-7):A61K9/20;A61K9/51 |
主分类号 |
C07D407/14 |
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