发明名称 |
DICAM-SPECIFIC ANTIBODIES AND USES THEREOF |
摘要 |
Novel antibodies directed against Dual Ig domain containing cell adhesion molecule (DICAM) are described. These anti-DICAM antibodies are capable of detecting DICAM by Western blot and/or flow cytometry, blocking the interaction between DICAM and its ligand α Vβ3 integrin, and/or blocking the migration of inflammatory cytokine-secreting TH17 lymphocytes across the blood brain barrier. Uses of these antibodies or compositions comprising same for the diagnosis, prevention and/or treatment of autoimmune/inflammatory conditions, such as neuroinflammatory conditions, and for the targeting, identification and selection of inflammatory cytokine-secreting TH17 lymphocytes or precursor thereof are also disclosed. |
申请公布号 |
WO2016095046(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
WO2015CA51338 |
申请日期 |
2015.12.17 |
申请人 |
VAL-CHUM, LIMITED PARTNERSHIP |
发明人 |
PRAT, ALEXANDRE;GHANNAM, SOUFIANE |
分类号 |
C07K16/28;C07K16/18;C07K16/42;C12N5/0783 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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