Substituted indazole derivatives active as kinase inhibitors

摘要

The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

主权项

1. A compound of formula (I): wherein: Ar is a group selected from wherein: R1 is an optionally substituted heterocyclyl; R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, SOnR9, COR10, NR11R12, OR13 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, and C3-C6 cycloalkyl wherein:
R9 is NR11R12 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl;R10 is hydrogen, NR11R12, OR13 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl;R11 and R12, taken together with the nitrogen atom to which they are bound, may form an optionally substituted heterocyclyl group;R13 is hydrogen, COR10 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein R10 is as defined above;n is 0, 1 or 2; X is an optionally substituted straight or branched C1-C6 alkyl; Y is a bond or oxygen; Z is an optionally substituted straight or branched C1-C6 alkyl; Ar′ is an optionally substituted aryl or an optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof.