Alpha Connexin c-Terminal (ACT) peptides for use in transplant

摘要

The present disclosure provides compositions and methods for treating or preventing macular degeneration in a subject. The disclosure also provides compositions and methods for preserving organs and tissues for transplantation, and for preventing cellular injury in organs or in subjects.

主权项

1. A method of preserving an organ for organ transplantation comprising incubating the organ with a solution comprising an isolated polypeptide consisting of the carboxy terminal most 4 to 30 contiguous amino acids of an alpha connexin, or a conservative variant thereof.