SEMI-PERMEABLE MICROCAPSULE WITH COVALENTLY LINKED LAYERS AND METHOD FOR PRODUCING SAME

摘要

The present invention relates to semi-permeable microcapsules, which exhibit an increased resistance to mechanical stresses as well as an increas ed resistance to chemical degradation. More specifically, this semi-permeable microcapsule has a bead enclosing a material such as living cells, covalentl y linked to a semi-permeable layer, made of a polycation cross-linking derivative, covering the bead. The present invention is also directed to a pharmaceutica l composition comprising the above-mentioned semi-permeable microcapsules. The present invention is also directed to the use of such microcapsule in a meth od for microencapsulating a beaded material and in a method for treating diabetes i n a subject.