The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
申请公布号
WO9733904(A1)
申请公布日期
1997.09.18
申请号
WO1996US16849
申请日期
1996.10.17
申请人
HUMAN GENOME SCIENCES, INC.;THE REGENTS OF THE UNIVERSITY OF MICHIGAN;YU, GUO-LIANG;NI, JIAN;DIXIT, VISHVA, M.;GENTZ, REINER, L.;DILLON, PATRICK, J.
发明人
YU, GUO-LIANG;NI, JIAN;DIXIT, VISHVA, M.;GENTZ, REINER, L.;DILLON, PATRICK, J.