发明名称 |
Annexin derivatives with endogenous chelation sites |
摘要 |
Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X<SUB>1</SUB>-Gly-X<SUB>2</SUB>, where X<SUB>1 </SUB>and X<SUB>2 </SUB>are selected from Gly and Cys, where at least one of X<SUB>1 </SUB>or X<SUB>2 </SUB>is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.
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申请公布号 |
US2005095198(A1) |
申请公布日期 |
2005.05.05 |
申请号 |
US20040012708 |
申请日期 |
2004.12.15 |
申请人 |
UNIVERSITY OF WASHINGTON |
发明人 |
TAIT JONATHAN F.;BROWN DAVID S. |
分类号 |
A61K38/16;A61K51/00;A61K51/08;C07K1/00;C07K5/083;C07K14/435;C07K14/47;(IPC1-7):A61K51/00;A61K49/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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