PROCESSES FOR THE PREPARATION OF PANCRATISTATIN AND PANCRATISTATIN ANALOGUES
摘要
<p>Processes for the preparation of pancratistatin and pancratistatin analogues. The key step is the reaction of a 1,3-dioxan-5-one and a nitroolefine in the presence of an amine. The process may take place in an enantioselective way when a chiral amine is used. Reduction processes then give new and advanced intermediates that are useful for the preparation of pancratistatin or selected pancratistatin analogues. The reported process also provides a method for the efficient synthesis of nitroenals, starting materials of the synthesis. Analogues of pancratistatin are also provided.</p>
申请公布号
WO2009026961(A1)
申请公布日期
2009.03.05
申请号
WO2007EP59072
申请日期
2007.08.30
申请人
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA;ALONSO ALONSO, RICARDO;OZORES VITURRO, LIDIA;CAGIDE FAGIN, FERNANDO;ORTIZ LARA, JUAN CARLOS
发明人
ALONSO ALONSO, RICARDO;OZORES VITURRO, LIDIA;CAGIDE FAGIN, FERNANDO;ORTIZ LARA, JUAN CARLOS