Human neonatal Fc receptor antibodies and methods of use thereof

摘要

The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.

主权项

1. An isolated antibody comprising a light chain variable region (VL), a heavy chain variable region (VH), and a heavy chain constant region (CH), wherein the antibody binds to human neonatal Fc receptor (FcRn); and wherein
the VL comprises: (i) a VL CDR1 comprising the amino acid sequence TGTGSDVGSYNLVS (SEQ ID NO:14); (ii) a VL CDR2 comprising the amino acid sequence GDSQRPS (SEQ ID NO:15); and (iii) a VL CDR3 comprising the amino acid sequence SSYAGSGIYV (SEQ ID NO:12) or ASYAGSGIYV (SEQ ID NO:13); and the VH comprises: (i) a VH CDR1 comprising the amino acid sequence EYAMG (SEQ ID NO:22); (ii) a VH CDR2 comprising the amino acid sequence SIGSSGGQTKYADSVKG (SEQ ID NO:23); and (iii) a VH CDR3 comprising the amino acid sequence LAIGDSY (SEQ ID NO:24); and the CH has a deletion corresponding to the C-terminal lysine residue at the last position of SEQ ID NO:17.