Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands

摘要

Compounds provided herein are novel substituted tetrahydropurinones of Formula (I): wherein R³ is aryl substituted with 0-5 X^Ar or heteroaryl substituted with 0-4 X^hAr. Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression.