发明名称 CCR2のシクロヘキシル−アゼチジニルアンタゴニスト
摘要 The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
申请公布号 JP5937580(B2) 申请公布日期 2016.06.22
申请号 JP20130514354 申请日期 2011.06.09
申请人 ヤンセン ファーマシューティカ エヌ.ベー. 发明人 チャン,スークイン;スイ,チーホア;ランター,ジェームズ,シー.
分类号 C07D401/14;A61K31/416;A61K31/4178;A61K31/422;A61K31/423;A61K31/427;A61K31/437;A61K31/4439;A61K31/451;A61K31/695;A61P1/02;A61P1/04;A61P3/00;A61P3/04;A61P3/10;A61P9/04;A61P9/10;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P25/00;A61P27/02;A61P27/12;A61P29/00;A61P31/04;A61P31/06;A61P35/00;A61P35/02;A61P37/06;A61P37/08;A61P43/00;C07D403/12;C07D403/14;C07D405/14;C07D413/12;C07D413/14;C07D417/14;C07D471/04;C07F7/18 主分类号 C07D401/14
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