摘要 |
The present invention relates to a class of compounds represented by the Formula I Wherein A<SUP>1 </SUP>is a pyridinyl of the formula optionally substituted by one or more R<SUP>k </SUP>selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and -COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alpha<SUB>v</SUB>beta<SUB>3 </SUB>and/or alpha<SUB>v</SUB>beta<SUB>5 </SUB>integrin.
|