Attenuation-based optic neuropathy detection with three-dimensional optical coherence tomography

摘要

Optical coherence tomography (OCT) scan data of a subject is acquired over a region of interest which can include an optic disc or a macula of a retina. Layer boundaries of retinal layers are identified in the OCT scan data to facilitate measurements. In one aspect, a measurement related to ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers is computed on a location-by-location basis within a region of interest of the OCT scan data. Measurements can be collected, aggregated, analyzed, and displayed in connection with other information taken or derived from the OCT scan data.

主权项

1. A method for detecting and monitoring diseases, comprising:
obtaining imaging data of a region of the retina; identifying boundaries between layers of the retina in the region of the retina, based on the imaging data; and determining, on a location-by-location basis for at least a portion of the region of the retina, a measurement value related to a ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers to generate a set of measurement values for locations in the portion of the region of the retina, wherein the measurement value is generally monotonic with respect to an integrated attenuation value such that the ratio value is used as a proxy measurement for the integrated attenuation value.