发明名称 |
6-AZIDO-2-FLUOROPURINE, USEFUL IN THE SYNTHESIS OF NUCLEOSIDES |
摘要 |
This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate. In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.
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申请公布号 |
US5180824(A) |
申请公布日期 |
1993.01.19 |
申请号 |
US19900620236 |
申请日期 |
1990.11.29 |
申请人 |
BERLEX BIOSCIENCES INC. |
发明人 |
BAUMAN, JOHN G.;WIRSCHING, RANDOLPH C. |
分类号 |
C07D473/40;C07H19/16;C07H19/20 |
主分类号 |
C07D473/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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