| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of quinoxaline of the formula (I) <EMI ID=0.301 HE=39 WI=39 TI=CHI> where A - nitrogen or CH; R<SP>1</SP>,R - alkyl, halide or <EMI ID=0.302 HE=9 WI=6 TI=CHI>; R - H, cycloalkyl or alkyl possibly substituted with hydroxy-, alkoxy-group, phenyl, pyridinyl, morpholinyl, benzimidazolyl, pyrazolyl, ozoxazol or phthalimidyl, C<SB>2-6</SB>-alkenyl, C<SB>2-6</SB>-alkynyl, C<SB>2-6</SB>-alkanoyl, carboxy-group, aminoalkoxycarbonyl, alkylamino-, dialkylamino- -group, NHSO<SB>2</SB>CF<SB>3</SB>, CONR<SP>5</SP>R<SP>6</SP>, O(CH<SB>2</SB>)<SB>n</SB>NR<SP>5</SP>R<SP>6</SP>, NHCO-NR<SP>5</SP>R<SP>6</SP>;; R<SP>5</SP>, R - H, alkyl or in common with nitrogen atom form pyrrolidino- or morpholino-group; n = 2, 3 or 4, and their pharmaceutically acceptable salts that show anxiolytic, anticonvulsant, analgetic or neuroprotective activity. EFFECT: improved method of synthesis, valuable pharmacological activity. 15 cl, 3 tbl, 30 ex
|
