Pyrazole compounds useful as protein kinase inhibitors

摘要

Pyrazole compounds of formula (IV) are described. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, and for treating diseases such as cancer, diabetes, AlzheimersÆs disease, HuntingtonÆs disease, ParkinsonÆs disease, AIDS-associated dementia, amyotrophic lateral sclerosis, multiple scerosis, schizophrenia, cardiomycete hypertrophy, reperfusion/ischemia and baldness. The compounds are also useful in the manufacture of a medicament for enhancing glycogen synthesis or lowering blood levels of glucose, for inhibiting the production of hyperphosphorylated Tau protein or for inhibiting the phosphorylation of beta-catenin.