| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein:
Ring A is a saturated 4-8 membered monocyclic or bridged heterocyclic ring having one —N(R1)—, a saturated 7-11 membered spirofused heterocyclic ring having one —N(R1)—, or a saturated 8-10 membered bicyclic heterocyclic ring having one —N(R1)—, wherein Ring A is substituted with 0-3 Rv groups;R1 is -L-Y, wherein:L is an optionally substituted bivalent C2-8 unsaturated, straight or branched, hydrocarbon chain, wherein one, two, or three methylene units of L are optionally and independently replaced by cyclopropylene, —N(R)—, —N(R)C(O)—, —C(O)N(R)—, —N(R)SO2—, —SO2N(R)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —SO—, —SO2—, —C(═S)—, —C(═NR)—, —N═N—, or —C(═N2)—; andY is hydrogen, halogen, —CN, C1-6 aliphatic optionally substituted with oxo, halogen, or CN, or a 3-10 membered monocyclic or bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein said ring is substituted with 1-4 groups independently selected from -Q-Z, oxo, —NO2, halogen, —CN, and C1-6 aliphatic, wherein:
Q is a covalent bond or a bivalent C1-6 saturated or unsaturated, straight or branched, hydrocarbon chain, wherein one or two methylene units of Q are optionally and independently replaced by —N(R)—, —S—, —O—, —C(O)—, —SO—, or —SO2—; andZ is hydrogen or C1-6 aliphatic optionally substituted with oxo, halogen, or CN;Ring B is a saturated 5-7-membered heterocyclo ring having 1-2 nitrogen atoms, wherein Ring B is substituted with 0-5 Rx groups;W is —N(R2)CH2— or —NH—;R2 is selected from hydrogen, C1-6 aliphatic or —C(O)R;R3 and R4 are each independently selected from hydrogen or halogen;each R group is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated carbocyclic ring, a 4-7 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;Ry is hydrogen, halogen, —CF3, or C1-4 aliphatic;each Rx is independently oxo, halogen, —OR, —N(R)2, —S(O)xR, —N(R)(CH2)qN(R)2, —N(R)(CH2)qOR, —O(CH2)qOR, —O(CH2)qN(R)2, an optionally substituted C2-6 saturated, straight or branched, hydrocarbon chain wherein one or two methylene units are independently replaced by —O—, —N(R)— or —S(O)x—, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated carbocyclic ring, a 4-7 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;each Rv is independently selected from halogen or C1-6 aliphatic;q is 1 or 2; andeach x is 0, 1 or 2. |
