Polylactide and calcium phosphate compositions and methods of making the same

摘要

A method is provided for synthesizing polylactide/calcium phosphate composites. In one aspect, an intermediate silanized calcium phosphate material calcium-phosphate/phosphonate is developed to improve the tensile strength of the composite.

主权项

1. A method for preparing a polylactide/calcium phosphate containing material comprising the steps of:
combining a calcium phosphate material having a general formula of Cap(PO4)qXz, where p=1-10, q=1-10 and z=1-5 and where X may be O, CO3, F, Cl, Br with a silane material haying a general formula of (R1O)(R2O)(R3O)Si—R4—Y, where Y can be OH, NH2, SH, Cl; R1, R2, R3 can be the same or different C1-C10 alkyl, R4 is C1-C20 alkyl, to form an intermediate silanized calcium phosphate material; and combining polymer selected from the group consisting of a lactide material haying a general formula of —(OCR1R2CO)n— or —(R3COO)n—, where R1, R2, R3 can be any of H, alkyl less than C10, polyglycolide, polylactide-co-glycolide, polycaprolactone and mixtures thereof with the intermediate silanized calcium phosphate material to form the polylactide/calcium phosphate material initiated.