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1. Method for evaluation of myocardial damage based on evaluating and scoring current density variations derived from magnetocardiographic data, wherein indication of ventricular damage is determined based evaluating and scoring of eleven quantitative indicators, comprising:
reconstructing current density distribution maps in the frontal plane and calculating current density vector lengths for each map during the cardio-cycle, and wherein the QRS complex of the cardio-cycle is divided into four sub-intervals (1)-(4), which represent the (1) depolarization of the interventricular septum, (2) anterior wall and apex of the left ventricle LV, (3) left ventricle side wall, and (4) basal myocardial regions; and generating a score for each of eleven following indicators:
(1) wherein the total current for each density distribution map is calculated during the cardio-cycle, and the total current curve is plotted onto the ST-T interval, and the ST segment duration is calculated as point J to T wave beginning, and the ratio of the ST segment duration to the ST-T interval duration is obtained, and, wherein diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, if said ratio is less than 25%, 25% to 35%, or more than 35%, respectively;(2) wherein, a curve of total current is calculated during the QRS complex as Q point to J point, and diagnosis is made concerning absence of, presence of minor, or presence of significant, ventricular damage, if the QRS complex duration is less than 0.11 s, 0.11 s to 0.14 s, or more than 0.14 s, respectively;(3) wherein curves of total current are calculated for the four-sub-intervals (1)-(4) of the QRS complex and the ratios of the curves of total current to the corresponding expected values known from electrophysiology are derived, and diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, according to whether one of the four ratios, is ranged from 0.8 to 1.2, from 0.7 to 0.8 or 1.2 to 1.5, or lower than 0.7 or higher than 1.5, respectively:(4) wherein an arithmetic mean is calculated of the four ratios and diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, if the calculated arithmetic mean is ranged from 0.8 to 1.2, from 0.7 to 0.8 or 1.2 to 1.5, or lower than 0.7 or higher than 1.5, respectively;(5) wherein the QRS complex contains negative waves, the negative waves are counted and diagnosis made concerning absence of, presence of minor, or presence of significant ventricular damage, if the number of negative waves is less than 1, from 2 to 3, or more than 3, respectively;(6) wherein a time dependence is calculated of the correlation coefficient for an instant map with a map taken on the T wave peak during the ST-T interval, from which a ratio of ST segment duration to ST-T interval duration is calculated, and diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, if said ratio is less than 25%, 25% to 35%, or more than 35%, respectively;(7) wherein a difference is calculated between the maximum correlation coefficient on the T wave peak and its value in the fourth point of ST-T interval, which is 40 ms after J point, and diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, if said difference is less than 30%, from 30% to 50%, or more than 50%, respectively;(8) wherein a time dependence is calculated of the correlation coefficients for an instant map with a map taken on the R-wave peak during the QRS complex, and diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, if a curve of the time dependence at moments of rapid curve increase/decrease contains respectively, 2, 1, or 0 characteristic inflection points;(9) wherein a time dependence is calculated of the autocorrelation coefficient for an instant map during the QRS complex, and diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, if a curve of the time dependence contains respectively, 2, 1, or 0;(10) wherein average correlation coefficients are calculated on the ST-T interval and QRS complex and diagnosis is made concerning absence of, presence of minor, or presence of significant ventricular damage, if the average correlation coefficient on the ST-T interval is higher than 75%, 60% to 75%, or lower than 60%, respectively, and;(11) a diagnosis is make concerning absence of, presence of minor, or presence of significant ventricular injury, wherein, if the average correlation coefficient on the QRS complex is lower than 41%, 41% to 60%, or more than 60%, respectively; wherein each quantitative indicator is scored with 0 points if a diagnosis of absence of ventricular damage is made for that quantitative indicator, with 1 point if a diagnosis of presence of minor ventricular damage is made for that quantitative indicator, and with 2 points if a diagnosis of presence of significant damage is made for that quantitative indicator; and wherein, an overall diagnosis is provided concerning absence of, presence of minor, or presence of significant ventricular damage, if the sum of points for all said quantitative indicators is less than or equal to 7, from 8 to 16, or 17 or more, respectively. |
