Pre-treatment process for electrochemical amperometric sensor

摘要

A wearable device is provided herein and includes an electrochemical sensor with a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte. In accordance with one embodiment, a process is provided herein and includes applying an electric potential waveform pattern between the working electrode and the reference electrode, the pattern comprising a combination of a constant voltage and at least one voltage waveform including one or more of a triangle waveform, a pulse-step waveform, and a sine waveform, determining a current at the working electrode, the current resulting from the application of the electric potential waveform pattern, determining that the current is less than a threshold level of measured current, and in response, the wearable device stopping the application of the electric potential waveform pattern.

主权项

1. A system comprising:
a wearable device comprising:
an antenna;an electrochemical sensor that includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte; anda controller electrically connected to the electrochemical sensor and the antenna, wherein the controller is configured to control the electrochemical sensor to obtain a sensor measurement while the wearable device is exposed to a fluid, and use the antenna to transmit the sensor measurement; and a reader operable in a pre-treatment mode and a measurement mode,
wherein in the pre-treatment mode the reader is configured to (i) wirelessly communicate with the antenna to cause the electrochemical sensor to apply an electric potential waveform pattern between the working electrode and the reference electrode, the pattern comprising a combination of a constant voltage and at least one voltage waveform including one or more of a triangle waveform, a pulse-step waveform, and a sine waveform, (ii) wirelessly communicate with the antenna to receive a pre-treatment measurement obtained while the wearable device is exposed to a buffer solution substantially devoid of the analyte, (iii) determine that the pre-treatment measurement is less than a threshold level, and (iv) in response to the determination, wirelessly communicate with the antenna to cause the wearable device to stop applying the electric potential waveform pattern, andwherein in the measurement mode the reader is configured to wirelessly communicate with the antenna to receive a tear-film sensor measurement obtained with the wearable device exposed to a tear film and determine a concentration of the analyte in the tear film based on the tear-film sensor measurement.