发明名称 |
CHIMERIC TAR ENZYME CONSTRUCTION FOR HIV THERAPY |
摘要 |
The present invention relates to molecular chimaeras, infective virions, to methods of their construction, to pharmaceutical formulations containing them, to their use in therapy, particularly virus-directed enzyme prodrug therapy particularly in the treatment of HIV, and to the use of agents which can be catalysed by a heterologous enzyme to cytotoxic or cytostatic metabolites, such as purine arabinosides and substituted pyrimidines in virus-directed enzyme prodrug therapy, in a mammalian host (e.g. human). |
申请公布号 |
WO9215693(A1) |
申请公布日期 |
1992.09.17 |
申请号 |
WO1992GB00341 |
申请日期 |
1992.02.26 |
申请人 |
THE WELLCOME FOUNDATION LIMITED |
发明人 |
HUBER, BRIAN;RICHARDS, CYNTHIA, ANN;MARTIN, JEAN, LOUISE |
分类号 |
A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K38/00;A61K48/00;A61P31/12;C07H19/09;C07H19/19;C07K14/16;C12N9/12 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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