| 发明名称 |
Methods and Compositions for Targeting Tumor Microenvironment and for preventing Metastasis |
| 摘要 |
The invention relates to the invention relates to methods and compositions for targeting tumor microenvironment (TME) and for preventing metastasis. The invention also relates to methods and compositions for inhibiting the pro-invasive stromal fibroblast activity as well as the pro-invasive stromal fibroblast activation in a patient in need thereof such as a patient affected with a solid cancer. |
| 申请公布号 |
US2016237158(A1) |
申请公布日期 |
2016.08.18 |
| 申请号 |
US201415023806 |
申请日期 |
2014.09.23 |
| 申请人 |
INSTITUT NATIONAL DE LA SANTÉ ET DA LA RECHERCHE MÉDICALE (INSERM) ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ;UNIVERSITE NICE SOPHIA ANTIPOLIS |
发明人 |
GAGGIOLI Cedric;MENEGUZZI Guerrino;ALBRENGUES Jean |
| 分类号 |
C07K16/28;C12Q1/68;A61K31/7064;G01N33/574;A61K31/519;C07K16/24 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating or preventing metastasis in a patient affected with a Leukemia Inhibitory Factor (LIF)-expressing solid cancer, comprising administering to the patient a therapeutically effective amount of an inhibitor of the Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) signalling pathway. |
| 地址 |
Paris FR |
