1-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-B]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy

摘要

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (for convenience, collectively referred to herein as “IP compounds”), which, inter alia, are useful in the treatment of cancer, e.g., cancer characterised by (e.g., driven by) mutant RAS (“mutant RAS cancer”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions in the treatment of cancer, e.g., mutant RAS cancer.;

主权项

1. A method of treatment of mutant RAS cancer, comprising administering to a subject in need of treatment a therapeutically-effective amount of a compound selected from compounds of the following formula, and pharmaceutically acceptable salts thereof: wherein -J- is independently: and wherein —R is independently: —H, -Me, —F, —Cl, —Br, or —I; and wherein —R is positioned meta- or para- on the phenyl ring, wherein the mutant RAS cancer is mutant RAS melanoma or mutant RAS colorectal cancer.