| 摘要 |
The invention relates to a method for making a laminated microfluidics with membrane valves. The method comprises (a) generating a membrane valve assembly comprising (1) laminating three plastic foils together, the top foil comprising one through hole for each valve, the middle foil has a slit pattern connecting each valve hole of the top foil, and the bottom foil has one through hole for each valve and one additional hole entering the slit pattern; (2) placing the laminated foil, bottom foil down on a mould half having a smooth mould surface with one or more perpendicularly protruding cylinders that concentrically fit within the through holes of the laminated foil yet leave room for a membrane to form, and clamping a second mould half to close the mould; (3) injecting and allowing to cure a liquid rubber through a funnel associated with the bottom mould half and the additional hole on the bottom foil layer; and (b) laminating the membrane valve assembly and a flow path. Also provided is a membrane valve assembly made according to the method. |
| 主权项 |
1. A method for making laminated microfluidics with membrane valves, said method comprising:
a) generating a membrane valve assembly comprising (1) laminating three plastic foils together, the first, top foil comprising one through hole for each valve, the second, middle foil has a slit pattern connecting each valve hole of the top foil, and the third, bottom foil has one through hole for each valve and one additional hole entering the slit pattern; (2) placing the laminated foil, bottom foil down on a mould half having a smooth mould surface with one or more perpendicularly protruding cylinders that concentrically fit within the through holes of the laminated foil yet leave room for a membrane to form, and damping a second mould half to close the mould; (3) injecting and allowing to cure a liquid rubber through a funnel associated with the bottom mould half and the additional hole on the bottom foil layer; and b) laminating the membrane valve assembly and a flow path comprising a fourth and a fifth plastic foil, wherein the fourth foil contains a slit pattern, with the fourth foil on top of the first foil and the fifth foil on top of the fourth foil. |
