发明名称 |
THERAPEUTIC AND DIAGNOLSTIC METHODS FOR CANCER |
摘要 |
The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on expression levels of a biomarker of the invention (e.g., PD-L1 expression levels in tumor-infiltrating immune cells in a tumor sample obtained from the patient) and/or based on the determination of a tumor sample subtype. |
申请公布号 |
WO2016196298(A1) |
申请公布日期 |
2016.12.08 |
申请号 |
WO2016US34664 |
申请日期 |
2016.05.27 |
申请人 |
GENENTECH, INC.;F. HOFFMANN-LA ROCHE AG |
发明人 |
HEGDE, Priti;KOWANETZ, Marcin;FINE, Gregg;MARIATHASAN, Sanjeev;BOURGON, Richard |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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