| 发明名称 |
INTEGRIN RECEPTOR ANTAGONISTS |
| 摘要 |
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, and tumor growth and metastasis.
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| 申请公布号 |
WO0006169(A1) |
申请公布日期 |
2000.02.10 |
| 申请号 |
WO1999US16830 |
申请日期 |
1999.07.26 |
| 申请人 |
MERCK & CO., INC.;DUGGAN, MARK, E.;HARTMAN, GEORGE, D. |
发明人 |
DUGGAN, MARK, E.;HARTMAN, GEORGE, D. |
| 分类号 |
A61K31/4178;A61K31/4184;A61K31/4375;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4439;A61K31/505;A61K31/506;A61K45/06;A61P19/02;A61P19/10;A61P27/02;A61P29/00;A61P31/12;A61P35/00;A61P35/04;C07D213/73;C07D239/14;C07D239/42;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D409/14;C07D471/04;(IPC1-7):A61K31/505;A61K31/435;A61K31/415;C07D401/10;C07D403/10 |
主分类号 |
A61K31/4178 |
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