发明名称 |
composições e métodos de tratamento de neoplasia, doença inflamatória e outros distúrbios |
摘要 |
The invention features compositions for treating or preventing a neoplasia. More specifically, the invention provides thienotriazolodiazepine compounds for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail). |
申请公布号 |
BR112012029005(A2) |
申请公布日期 |
2016.07.26 |
申请号 |
BR20121129005 |
申请日期 |
2011.05.16 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
JAMES ELLIOTT BRADNER;JUN QI |
分类号 |
A61K31/555;A61K31/553 |
主分类号 |
A61K31/555 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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