NOVEL SUBSTITUTED N, N-DIMETHYLAMINOALKYL ETHERS OF ISOFLAVANONE OXIMES AS H1-RECEPTOR ANTAGONISTS

摘要

The present invention relates to compounds of formula (I), and salts thereof and the pharmaceutical composition containing them in treatment of various diseases, as allergic rhinitis where R1 and R2 are, independently, hydrogen, halogen, C1_3 alkyl or C1-3alkoxy; R3 is phenyl optionally substituted by R4 and R5 which are, independently hydrogen, halogen, C1-3 alkyl, C1-3-alkoxy, fluoro-, difluoro- and trifluoromethyl, nitrile group, N,N-diC1-3alkyl-amide, carboC1-3 alkoxy or C1-3alkylsulphone groups; R3 is pyridyl group containing nitrogen at various positions in the benzene ring, n is one of the integers 1 or 2.;

主权项

1. A compound, including enantiomers, stereoisomers, cis-, trans-isomers and their racemic mixture and mixture of geometric isomers, or pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in formula (I)whereinR1 and R2 are, independently, hydrogen, halogen, C1-3alkyl or C1-3alkoxy;R3 is phenyl optionally substituted by R4 and R5 which are, independently hydrogen, halogen, C1-3alkyl, C1-3alkoxy, fluoro-, difluoro- and trifluoromethyl, nitrile group, N,N-diC1-3alkylamide, carboC1-3alkoxy or C1-3alkylsulphone groups; R3 is pyridynyl group containing nitrogen at various positions in the benzene ring. n is one of the integers 1 or 2.