| 发明名称 | Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen | ||
| 摘要 | The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility complex (MHC). The invention provides a method of activating a signaling pathway and/or killing a cancer cell using a receptor that is similar to or is a T cell receptor. | ||
| 申请公布号 | US9469684(B2) | 申请公布日期 | 2016.10.18 |
| 申请号 | US201313939988 | 申请日期 | 2013.07.11 |
| 申请人 | University of Pittsburgh—Of the Commonwealth System of Higher Education | 发明人 | Finn Olivera J.;Alajez Nehad M.;Schmielau Jan;Alter Mark D. |
| 分类号 | C12N5/07;C07K14/705;C07K14/725;C07K16/28;C07K16/30;A61K38/00 | 主分类号 | C12N5/07 |
| 代理机构 | Leydig, Voit & Mayer, Ltd. | 代理人 | Leydig, Voit & Mayer, Ltd. |
| 主权项 | 1. An isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of a major histocompatibility complex (MHC), wherein the receptor is an scFv and a. comprises a first amino acid sequence that is identical with the portion of MA Vα23 shown in FIG. 1 (SEQ ID NO:1) and b. comprises a second amino acid sequence that is identical with the portion of MA Vβ8.3 shown in FIG. 1 (SEQ ID NO:2). | ||
| 地址 | Pittsburgh PA US | ||