PROTEIN TYROSINE PHOSPHATASE INHIBITOR, PREPARATION METHOD AND USES THEREOF

摘要

Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the Isaria Fumosorosea Wize solid or liquid fermentation broth using ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol; separating the obtained extract using column chromatography on silica gel; and obtaining the target product. The inhibitor can be used to prepare pharmaceutical compositions for treating and preventing diabetes, obesity and cancers.

主权项

1. A method for treating diabetes, obesity and cancers in a subject in need thereof, the method comprising:
administering a composition comprising a protein tyrosine phosphatase inhibitor and a pharmaceutically acceptable carrier to the subject, wherein the composition is administered in an effective amount, wherein the protein tyrosine phosphatase inhibitor is the following (a) or (b): (a) a compound having the following structural formula: (b) an isomer of compound (a) or a pharmaceutically acceptable derivative thereof.