d-Methadone for the Treatment of Psychiatric Symptoms

摘要

The present invention relates to a method of treating psychiatric symptoms in a subject having a NMDA receptor and a NE receptor which includes administering d-methadone, d-methadol, d-alpha-acetylmethadol, l-alpha-acetylmethadol, d-alpha-normethadol, l-alpha-normethadol, pharmaceutically acceptable salts thereof, or mixtures thereof, to the subject under conditions effective for the substance to bind to the NMDA receptor and NE receptor of the subject.

主权项

1. A method of treating psychological and psychiatric symptoms comprising:
administering a composition to a subject suffering from one or more psychological symptoms chosen from depression, anxiety, fatigue, and mood instability including pseudo-bulbar affect, the composition including, as the sole active agent in the composition for treating said one or more psychological symptoms, an NMDA receptor antagonist selected from d-methadone, d-methadol, d-alpha-acetylmethadol, d-alpha-normethadol, l-alpha-normethadol, and pharmaceutically acceptable salts thereof; wherein the NMDA receptor antagonist is isolated from its enantiomer or synthesized de novo; and wherein the administering of the composition occurs under conditions effective for the NMDA receptor antagonist to bind to an NMDA receptor of the subject and thereby relieve the subject from said one or more psychological symptoms; and administering a psychiatric drug to the subject in combination with the administering of the composition, wherein the psychiatric drug is selected from CNS stimulants, opioids, nicotine, and other NMDA receptor antagonists.