发明名称 |
CHIMERIC ANTIGEN RECEPTOR COMPOSITIONS |
摘要 |
Provided herein are compositions which exhibit novel diagnostic capabilities and allow to rapidly add functionality to adoptive immunotherapy. The compositions include isolated nucleic acids encoding proteins including antibody regions capable of binding compounds including a peptidyl moiety (e.g., a meditope). The recombinant proteins provided herein are useful, inter alia, for a broad variety of therapeutic and diagnostic purposes. For example, the recombinant proteins provided herein including embodiments thereof may be used as non-invasive means to characterize chimeric antigen receptor (CAR) T cells before and/or during treatment of diseases (e.g., cancer). |
申请公布号 |
WO2016187158(A1) |
申请公布日期 |
2016.11.24 |
申请号 |
WO2016US32780 |
申请日期 |
2016.05.16 |
申请人 |
CITY OF HOPE |
发明人 |
WILLIAMS, John, C.;BROWN, Christine |
分类号 |
C07K14/435;C07K16/28;C12N5/10;C12N9/00;C12N15/09;C12N15/63 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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