TRANSGENIC ANIMALS WITH MUTANT HUMAN APP OR A4CT SEQUENCES
摘要
Constructs comprising a human APP or A4CT DNA sequence encoding mutations which lead to a higher ratio of beta A41-42/ beta A41-40 than wild type and their use in the production of transgenic animals developing amyloid plaques as a model of Alzheimer's disease.
申请公布号
WO9803643(A2)
申请公布日期
1998.01.29
申请号
WO1997EP03960
申请日期
1997.07.17
申请人
SMITHKLINE BEECHAM PHARMA GMBH;SMITHKLINE BEECHAM AUSTRALIA PTY. LTD.;LICHTENTHALER, STEFAN;PRIOR, PETER;MASTERS, COLIN, LOUIS;BEYREUTHER, KONRAD
发明人
LICHTENTHALER, STEFAN;PRIOR, PETER;MASTERS, COLIN, LOUIS;BEYREUTHER, KONRAD
